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119
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BMCBI
2010
153views more  BMCBI 2010»
14 years 12 months ago
GOAL: A software tool for assessing biological significance of genes groups
Background: Modern high throughput experimental techniques such as DNA microarrays often result in large lists of genes. Computational biology tools such as clustering are then us...
Alain B. Tchagang, Alexander Gawronski, Hugo B&eac...
BMCBI
2010
163views more  BMCBI 2010»
14 years 12 months ago
Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity
Background: Computational comparison of two protein structures is the starting point of many methods that build on existing knowledge, such as structure modeling (including modeli...
Zong Hong Zhang, Hwee Kuan Lee, Ivana Mihalek
92
Voted
BMCBI
2010
103views more  BMCBI 2010»
14 years 12 months ago
A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements
Background: Polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evid...
Alexander G. Churbanov, Igor Vorechovsky, Chindo H...
BMCBI
2010
101views more  BMCBI 2010»
14 years 12 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
BMCBI
2010
163views more  BMCBI 2010»
14 years 12 months ago
DraGnET: Software for storing, managing and analyzing annotated draft genome sequence data
Background: New "next generation" DNA sequencing technologies offer individual researchers the ability to rapidly generate large amounts of genome sequence data at drama...
Stacy Duncan, Ruchita Sirkanungo, Leslie Miller, G...