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BMCBI
2010
15 years 27 days ago
2010
Background: DNA replication is a fundamental biological process during S phase of cell division. It is initiated from several hundreds of origins along whole chromosome with diffe...
119
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BMCBI
2008
15 years 27 days ago
2008
Background: The regulation of gene expression is complex and occurs at many levels, including transcriptional and post-transcriptional, in metazoans. Transcriptional regulation is...
115
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BMCBI
2010
15 years 27 days ago
2010
Background: A relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined w...
99
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BMCBI
2008
15 years 27 days ago
2008
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
98
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BMCBI
2007
15 years 27 days ago
2007
Background: Similarity of sequences is a key mathematical notion for Classification and Phylogenetic studies in Biology. It is currently primarily handled using alignments. Howeve...