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110
Voted
BMCBI
2010
15 years 29 days ago
2010
Emerging knowledge of whole prokaryotic transcriptomes could validate a number of theoretical concepts introduced in the early days of genomics. What are the rules connecting gene...
103
Voted
BMCBI
2008
15 years 29 days ago
2008
Background: In cancer research, most clinical variables have already been investigated and are now well established. The use of transcriptomic variables has raised two problems: r...
BMCBI
2008
15 years 29 days ago
2008
Background: Microarray experiments generate vast amounts of data. The functional context of differentially expressed genes can be assessed by querying the Gene Ontology (GO) datab...
88
Voted
BMCBI
2007
15 years 29 days ago
2007
Background: Deficiencies in microarray technology cause unwanted variation in the hybridization signal, obscuring the true measurements of intracellular transcript levels. Here we...
104
Voted
BMCBI
2010
15 years 29 days ago
2010
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...