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BMCBI
2004
75views more  BMCBI 2004»
14 years 10 months ago
Structural characterization of genomes by large scale sequence-structure threading
Background: Using sequence-structure threading we have conducted structural characterization of complete proteomes of 37 archaeal, bacterial and eukaryotic organisms (including wo...
Artem Cherkasov, Steven J. M. Jones
BMCBI
2004
108views more  BMCBI 2004»
14 years 10 months ago
Enhanced protein domain discovery using taxonomy
Background: It is well known that different species have different protein domain repertoires, and indeed that some protein domains are kingdom specific. This information has not ...
Lachlan James M. Coin, Alex Bateman, Richard Durbi...
BMCBI
2004
81views more  BMCBI 2004»
14 years 10 months ago
Few amino acid positions in rpoB are associated with most of the rifampin resistance in Mycobacterium tuberculosis
Background: Mutations in rpoB, the gene encoding the subunit of DNA-dependent RNA polymerase, are associated with rifampin resistance in Mycobacterium tuberculosis. Several studi...
Michael P. Cummings, Mark R. Segal
BMCBI
2004
102views more  BMCBI 2004»
14 years 10 months ago
No statistical support for correlation between the positions of protein interaction sites and alternatively spliced regions
Background: Alternative splicing is an efficient mechanism for increasing the variety of functions fulfilled by proteins in a living cell. It has been previously demonstrated that...
Marc N. Offman, Ramil N. Nurtdinov, Mikhail S. Gel...
BMCBI
2004
102views more  BMCBI 2004»
14 years 10 months ago
Detection of transposable elements by their compositional bias
Background: Transposable elements (TE) are mobile genetic entities present in nearly all genomes. Previous work has shown that TEs tend to have a different nucleotide composition ...
Olivier Andrieu, Anna-Sophie Fiston, Dominique Anx...