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BMCBI
2004
14 years 10 months ago
2004
Background: Annotation of sequences that share little similarity to sequences of known function remains a major obstacle in genome annotation. Some of the best methods of detectin...
BMCBI
2004
14 years 10 months ago
2004
Background: Allelic-loss studies record data on the loss of genetic material in tumor tissue relative to normal tissue at various loci along the genome. As the deletion of a tumor...
BMCBI
2004
14 years 10 months ago
2004
Background: Increasingly researchers are turning to the use of haplotype analysis as a tool in population studies, the investigation of linkage disequilibrium, and candidate gene ...
BMCBI
2004
14 years 10 months ago
2004
Background: The functional selection and three-dimensional structural constraints of proteins in nature often relates to the retention of significant sequence similarity between p...
BMCBI
2004
14 years 10 months ago
2004
Background: The usefulness of log2 transformation for cDNA microarray data has led to its widespread application to Affymetrix data. For Affymetrix data, where absolute intensitie...