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114
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BMCBI
2005
122views more  BMCBI 2005»
15 years 10 days ago
Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein
Background: Recognition codes for protein-DNA interactions typically assume that the interacting positions contribute additively to the binding energy. While this is known to not ...
Jiajian Liu, Gary D. Stormo
114
Voted
BMCBI
2005
112views more  BMCBI 2005»
15 years 10 days ago
Integration of the Gene Ontology into an object-oriented architecture
Background: To standardize gene product descriptions, a formal vocabulary defined as the Gene Ontology (GO) has been developed. GO terms have been categorized into biological proc...
Daniel Shegogue, W. Jim Zheng
103
Voted
BMCBI
2005
77views more  BMCBI 2005»
15 years 10 days ago
Structural comparison of metabolic networks in selected single cell organisms
Background: There has been tremendous interest in the study of biological network structure. An array of measurements has been conceived to assess the topological properties of th...
Dongxiao Zhu, Zhaohui S. Qin
149
Voted
BMCBI
2005
126views more  BMCBI 2005»
15 years 10 days ago
GANN: Genetic algorithm neural networks for the detection of conserved combinations of features in DNA
Background: The multitude of motif detection algorithms developed to date have largely focused on the detection of patterns in primary sequence. Since sequence-dependent DNA struc...
Robert G. Beiko, Robert L. Charlebois
BMCBI
2005
212views more  BMCBI 2005»
15 years 10 days ago
PAGE: Parametric Analysis of Gene Set Enrichment
Background: Gene set enrichment analysis (GSEA) is a microarray data analysis method that uses predefined gene sets and ranks of genes to identify significant biological changes i...
Seon-Young Kim, David J. Volsky