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92
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BMCBI
2006
137views more  BMCBI 2006»
14 years 10 months ago
Bounded search for de novo identification of degenerate cis-regulatory elements
Background: The identification of statistically overrepresented sequences in the upstream regions of coregulated genes should theoretically permit the identification of potential ...
Jonathan M. Carlson, Arijit Chakravarty, Radhika S...
93
Voted
BMCBI
2006
150views more  BMCBI 2006»
14 years 10 months ago
CGAT: a comparative genome analysis tool for visualizing alignments in the analysis of complex evolutionary changes between clos
Background: The recent accumulation of closely related genomic sequences provides a valuable resource for the elucidation of the evolutionary histories of various organisms. Howev...
Ikuo Uchiyama, Toshio Higuchi, Ichizo Kobayashi
78
Voted
BMCBI
2006
116views more  BMCBI 2006»
14 years 10 months ago
MICA: desktop software for comprehensive searching of DNA databases
Background: Molecular biologists work with DNA databases that often include entire genomes. A common requirement is to search a DNA database to find exact matches for a nondegener...
William A. Stokes, Benjamin S. Glick
106
Voted
BMCBI
2006
131views more  BMCBI 2006»
14 years 10 months ago
Statistical modeling of biomedical corpora: mining the Caenorhabditis Genetic Center Bibliography for genes related to life span
Background: The statistical modeling of biomedical corpora could yield integrated, coarse-to-fine views of biological phenomena that complement discoveries made from analysis of m...
David M. Blei, K. Franks, Michael I. Jordan, I. Sa...
72
Voted
BMCBI
2006
82views more  BMCBI 2006»
14 years 10 months ago
Selection of antisense oligonucleotides based on multiple predicted target mRNA structures
Background: Local structures of target mRNAs play a significant role in determining the efficacies of antisense oligonucleotides (ODNs), but some structure-based target site selec...
Xiaochen Bo, Shaoke Lou, Daochun Sun, Wenjie Shu, ...