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68
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BMCBI
2006
124views more  BMCBI 2006»
14 years 10 months ago
Network-based de-noising improves prediction from microarray data
Background: Prediction of human cell response to anti-cancer drugs (compounds) from microarray data is a challenging problem, due to the noise properties of microarrays as well as...
Tsuyoshi Kato, Yukio Murata, Koh Miura, Kiyoshi As...
84
Voted
BMCBI
2006
94views more  BMCBI 2006»
14 years 10 months ago
Fly-DPI: database of protein interactomes for D. melanogaster in the approach of systems biology
Background: Proteins control and mediate many biological activities of cells by interacting with other protein partners. This work presents a statistical model to predict protein ...
Chung-Yen Lin, Shu-Hwa Chen, Chi-Shiang Cho, Chia-...
77
Voted
BMCBI
2006
117views more  BMCBI 2006»
14 years 10 months ago
The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
Cornelis A. Albers, Martijn A. R. Leisink, Hilbert...
98
Voted
BMCBI
2006
169views more  BMCBI 2006»
14 years 10 months ago
Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
Alexander E. Kel, Nico Voss, Ruy Jauregui, Olga V....
71
Voted
BMCBI
2006
109views more  BMCBI 2006»
14 years 10 months ago
iHOPerator: user-scripting a personalized bioinformatics Web, starting with the iHOP website
Background: User-scripts are programs stored in Web browsers that can manipulate the content of websites prior to display in the browser. They provide a novel mechanism by which u...
Benjamin M. Good, Edward A. Kawas, Byron Yu-Lin Ku...