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BMCBI
2005
223views more  BMCBI 2005»
14 years 10 months ago
Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling
Background: The completion of the sequencing of human, mouse and rat genomes and knowledge of cross-species gene homologies enables studies of differential gene expression in anim...
Hong Fang, Weida Tong, Roger Perkins, Leming M. Sh...
BMCBI
2005
113views more  BMCBI 2005»
14 years 10 months ago
Microarray scanner calibration curves: characteristics and implications
Background: Microarray-based measurement of mRNA abundance assumes a linear relationship between the fluorescence intensity and the dye concentration. In reality, however, the cal...
Leming M. Shi, Weida Tong, Zhenqiang Su, Tao Han, ...
BMCBI
2004
174views more  BMCBI 2004»
14 years 10 months ago
SeeGH - A software tool for visualization of whole genome array comparative genomic hybridization data
Background: Array comparative genomic hybridization (CGH) is a technique which detects copy number differences in DNA segments. Complete sequencing of the human genome and the dev...
Bryan Chi, Ronald J. deLeeuw, Bradley P. Coe, Calu...
BMCBI
2002
89views more  BMCBI 2002»
14 years 10 months ago
Sources of variability and effect of experimental approach on expression profiling data interpretation
Background: We provide a systematic study of the sources of variability in expression profiling data using 56 RNAs isolated from human muscle biopsies (34 Affymetrix MuscleChip ar...
Marina Bakay, Yi-Wen Chen, Rehannah H. A. Borup, P...
BMCBI
2002
129views more  BMCBI 2002»
14 years 10 months ago
SeqHound: biological sequence and structure database as a platform for bioinformatics research
Background: SeqHound has been developed as an integrated biological sequence, taxonomy, annotation and 3-D structure database system. It provides a high-performance server platfor...
Katerina Michalickova, Gary D. Bader, Michel Dumon...