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BMCBI
2007
165views more  BMCBI 2007»
14 years 10 months ago
Ab initio identification of human microRNAs based on structure motifs
Background: MicroRNAs (miRNAs) are short, non-coding RNA molecules that are directly involved in post-transcriptional regulation of gene expression. The mature miRNA sequence bind...
Markus Brameier, Carsten Wiuf
BMCBI
2007
127views more  BMCBI 2007»
14 years 10 months ago
Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines
Background: Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The no...
Jian Tian, Ningfeng Wu, Xuexia Guo, Jun Guo, Juhua...
BMCBI
2007
107views more  BMCBI 2007»
14 years 10 months ago
antiCODE: a natural sense-antisense transcripts database
Background: Natural antisense transcripts (NATs) are endogenous RNA molecules that exhibit partial or complete complementarity to other RNAs, and that may contribute to the regula...
Yifei Yin, Yi Zhao, Jie Wang, Changning Liu, Shugu...
BMCBI
2007
113views more  BMCBI 2007»
14 years 10 months ago
miRAS: a data processing system for miRNA expression profiling study
Background: The study of microRNAs (miRNAs) is attracting great considerations. Recent studies revealed that miRNAs play as important regulators of gene expression and some even a...
Feng Tian, Huayue Zhang, Xinyu Zhang, Chi Song, Yo...
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BMCBI
2007
104views more  BMCBI 2007»
14 years 10 months ago
Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation
Background: The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main...
Marija Cvijovic, Daniel Dalevi, Elizabeth Bilsland...