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BMCBI
2010
104views more  BMCBI 2010»
14 years 10 months ago
Using simple artificial intelligence methods for predicting amyloidogenesis in antibodies
Background: All polypeptide backbones have the potential to form amyloid fibrils, which are associated with a number of degenerative disorders. However, the likelihood that amyloi...
Maria Pamela C. David, Gisela P. Concepcion, Eduar...
BMCBI
2010
150views more  BMCBI 2010»
14 years 10 months ago
Automatic structure classification of small proteins using random forest
Background: Random forest, an ensemble based supervised machine learning algorithm, is used to predict the SCOP structural classification for a target structure, based on the simi...
Pooja Jain, Jonathan D. Hirst
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BMCBI
2010
101views more  BMCBI 2010»
14 years 10 months ago
Detection of copy number variation from array intensity and sequencing read depth using a stepwise Bayesian model
Background: Copy number variants (CNVs) have been demonstrated to occur at a high frequency and are now widely believed to make a significant contribution to the phenotypic variat...
Zhengdong D. Zhang, Mark B. Gerstein
BMCBI
2010
96views more  BMCBI 2010»
14 years 10 months ago
The Protein-DNA Interface database
The Protein-DNA Interface database (PDIdb) is a repository containing relevant structural information of Protein-DNA complexes solved by X-ray crystallography and available at the...
Tomás Norambuena, Francisco Melo
BMCBI
2010
130views more  BMCBI 2010»
14 years 10 months ago
Analysis of DNA strand-specific differential expression with high density tiling microarrays
Background: DNA microarray technology allows the analysis of genome structure and dynamics at genome-wide scale. Expression microarrays (EMA) contain probes for annotated open rea...
Luis Quintales, Mar Sánchez, Francisco Ante...