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BMCBI
2010
81views more  BMCBI 2010»
14 years 9 months ago
Empirical Bayes Analysis of Sequencing-based Transcriptional Profiling without Replicates
Background: Recent technological advancements have made high throughput sequencing an increasingly popular approach for transcriptome analysis. Advantages of sequencing-based tran...
Zhijin Wu, Bethany D. Jenkins, Tatiana A. Rynearso...
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BMCBI
2010
153views more  BMCBI 2010»
14 years 9 months ago
Pash 3.0: A versatile software package for read mapping and integrative analysis of genomic and epigenomic variation using massi
Background: Massively parallel sequencing readouts of epigenomic assays are enabling integrative genome-wide analyses of genomic and epigenomic variation. Pash 3.0 performs sequen...
Cristian Coarfa, Fuli Yu, Christopher A. Miller, Z...
BMCBI
2010
80views more  BMCBI 2010»
14 years 9 months ago
Sampling the conformation of protein surface residues for flexible protein docking
Background: The problem of determining the physical conformation of a protein dimer, given the structures of the two interacting proteins in their unbound state, is a difficult on...
Patricia Francis-Lyon, Shengyin Gu, Joel Hass, Nin...
BMCBI
2010
113views more  BMCBI 2010»
14 years 9 months ago
Probabilistic Principal Component Analysis for Metabolomic Data
Background: Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique fo...
Gift Nyamundanda, Lorraine Brennan, Isobel Claire ...
BMCBI
2010
76views more  BMCBI 2010»
14 years 9 months ago
Validation and characterization of DNA microarray gene expression data distribution and associated moments
Background: The data from DNA microarrays are increasingly being used in order to understand effects of different conditions, exposures or diseases on the modulation of the expres...
Reuben Thomas, Luis de la Torre, Xiaoqing Chang, S...