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BIOINFORMATICS
2010
116views more  BIOINFORMATICS 2010»
14 years 9 months ago
A principal skeleton algorithm for standardizing confocal images of fruit fly nervous systems
Motivation: The fruit fly (Drosophila melanogaster) is a commonly used model organism in biology. We are currently building a 3D digital atlas of the fruit fly larval nervous syst...
Lei Qu, Hanchuan Peng
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BMCBI
2010
112views more  BMCBI 2010»
14 years 9 months ago
A boundary delimitation algorithm to approximate cell soma volumes of bipolar cells from topographical data obtained by scanning
Background: Cell volume determination plays a pivotal role in the investigation of the biophysical mechanisms underlying various cellular processes. Whereas light microscopy in pr...
Patrick Happel, Kerstin Moller, Ralf Kunz, Irmgard...
BMCBI
2010
95views more  BMCBI 2010»
14 years 9 months ago
Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets
Background: Theme-driven cancer survival studies address whether the expression signature of genes related to a biological process can predict patient survival time. Although this...
Esteban Czwan, Benedikt Brors, David Kipling
BMCBI
2010
183views more  BMCBI 2010»
14 years 9 months ago
Active learning for human protein-protein interaction prediction
Background: Biological processes in cells are carried out by means of protein-protein interactions. Determining whether a pair of proteins interacts by wet-lab experiments is reso...
Thahir P. Mohamed, Jaime G. Carbonell, Madhavi Gan...
BMCBI
2010
146views more  BMCBI 2010»
14 years 9 months ago
Booly: a new data integration platform
Background: Data integration is an escalating problem in bioinformatics. We have developed a web tool and warehousing system, Booly, that features a simple yet flexible data model...
Long H. Do, Francisco F. Esteves, Harvey J. Karten...