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107
Voted
BMCBI
2005
2005
Phylogenetic reconstruction of ancestral character states for gene expression and mRNA splicing data
14 years 10 months ago
Background: As genomes evolve after speciation, gene content, coding sequence, gene expression, and splicing all diverge with time from ancestors with close relatives. A minimum e...
BMCBI
2005
14 years 10 months ago
2005
Background: A number of algorithms for steady state analysis of metabolic networks have been developed over the years. Of these, Elementary Mode Analysis (EMA) has proven especial...
BMCBI
2005
14 years 10 months ago
2005
Background: Cells react to changing intra- and extracellular signals by dynamically modulating complex biochemical networks. Cellular responses to extracellular signals lead to ch...
85
Voted
BMCBI
2005
14 years 10 months ago
2005
Background: Exhaustive methods of sequence alignment are accurate but slow, whereas heuristic approaches run quickly, but their complexity makes them more difficult to implement. ...
BMCBI
2005
14 years 10 months ago
2005
Background: Distance-based methods are popular for reconstructing evolutionary trees thanks to their speed and generality. A number of methods exist for estimating distances from ...