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BMCBI
2010
162views more  BMCBI 2010»
14 years 12 months ago
SNP-RFLPing 2: an updated and integrated PCR-RFLP tool for SNP genotyping
Background: PCR-restriction fragment length polymorphism (RFLP) assay is a cost-effective method for SNP genotyping and mutation detection, but the manual mining for restriction e...
Hsueh-Wei Chang, Yu-Huei Cheng, Li-Yeh Chuang, Che...
BMCBI
2010
177views more  BMCBI 2010»
14 years 12 months ago
Modular composition predicts kinase/substrate interactions
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...
Yichuan Liu, Aydin Tozeren
BMCBI
2007
135views more  BMCBI 2007»
14 years 12 months ago
LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise
Background: Mass spectrometry protein profiling is a promising tool for biomarker discovery in clinical proteomics. However, the development of a reliable approach for the separat...
Dante Mantini, Francesca Petrucci, Damiana Pierago...
BMCBI
2007
159views more  BMCBI 2007»
14 years 12 months ago
Detecting differential expression in microarray data: comparison of optimal procedures
Background: Many procedures for finding differentially expressed genes in microarray data are based on classical or modified t-statistics. Due to multiple testing considerations, ...
Elena Perelman, Alexander Ploner, Stefano Calza, Y...
CC
2008
Springer
133views System Software» more  CC 2008»
14 years 12 months ago
Hardness Amplification via Space-Efficient Direct Products
We prove a version of the derandomized Direct Product lemma for deterministic space-bounded algorithms. Suppose a Boolean function g : {0, 1}n {0, 1} cannot be computed on more th...
Venkatesan Guruswami, Valentine Kabanets
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