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BMCBI
2011
14 years 9 months ago
A Beta-Mixture Model for Dimensionality Reduction, Sample Classification and Analysis
Background: Patterns of genome-wide methylation vary between tissue types. For example, cancer tissue shows markedly different patterns from those of normal tissue. In this paper ...
Kirsti Laurila, Bodil Oster, Claus L. Andersen, Ph...
BMCBI
2011
14 years 9 months ago
Estimation of allele frequency and association mapping using next-generation sequencing data
Background: Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing...
Su Yeon Kim, Kirk E. Lohmueller, Anders Albrechtse...
BMCBI
2011
14 years 9 months ago
NeurphologyJ: an automatic neuronal morphology quantification method and its application in pharmacological discovery
Background: Automatic quantification of neuronal morphology from images of fluorescence microscopy plays an increasingly important role in high-content screenings. However, there ...
Shinn-Ying Ho, Chih-Yuan Chao, Hui-Ling Huang, Tza...
BMCBI
2011
14 years 9 months ago
Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities
Background: Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes. Un...
Yao Fu, Laura R. Jarboe, Julie A. Dickerson
BMCBI
2011
14 years 9 months ago
LAVA: An Open-Source Approach To Designing LAMP (Loop-Mediated Isothermal Amplification) DNA Signatures
Background: We developed an extendable open-source Loop-mediated isothermal AMPlification (LAMP) signature design program called LAVA (LAMP Assay Versatile Analysis). LAVA was cre...
Clinton Torres, Elizabeth A. Vitalis, Brian R. Bak...