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118
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BMCBI
2006
15 years 13 days ago
2006
Background: We present a general approach to perform association analyses in pedigrees of arbitrary size and structure, which also allows for a mixture of pedigree members and ind...
104
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BMCBI
2006
15 years 13 days ago
2006
Background: Many genome projects are left unfinished due to complex, repeated regions. Finishing is the most time consuming step in sequencing and current finishing tools are not ...
105
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BMCBI
2006
15 years 13 days ago
2006
Background: Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such...
120
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BMCBI
2006
15 years 13 days ago
2006
Background: The extended use of microarray technologies has enabled the generation and accumulation of gene expression datasets that contain expression levels of thousands of gene...
BMCBI
2006
15 years 13 days ago
2006
Background: Unigenic evolution is a powerful genetic strategy involving random mutagenesis of a single gene product to delineate functionally important domains of a protein. This ...