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143
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BMCBI
2010
122views more  BMCBI 2010»
15 years 4 months ago
An automated framework for understanding structural variations in the binding grooves of MHC class II molecules
Background: MHC/HLA class II molecules are important components of the immune system and play a critical role in processes such as phagocytosis. Understanding peptide recognition ...
Kalidas Yeturu, Tapani Utriainen, Graham J. L. Kem...
BMCBI
2010
146views more  BMCBI 2010»
15 years 4 months ago
Nonnegative principal component analysis for mass spectral serum profiles and biomarker discovery
Background: As a novel cancer diagnostic paradigm, mass spectroscopic serum proteomic pattern diagnostics was reported superior to the conventional serologic cancer biomarkers. Ho...
Henry Han
BMCBI
2010
134views more  BMCBI 2010»
15 years 4 months ago
BayesMotif: de novo protein sorting motif discovery from impure datasets
Background: Protein sorting is the process that newly synthesized proteins are transported to their target locations within or outside of the cell. This process is precisely regul...
Jianjun Hu, Fan Zhang
139
Voted
BMCBI
2010
108views more  BMCBI 2010»
15 years 4 months ago
Predicting changes in protein thermostability brought about by single- or multi-site mutations
Background: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostabilit...
Jian Tian, Ningfeng Wu, Xiaoyu Chu, Yunliu Fan
FCSC
2010
238views more  FCSC 2010»
15 years 2 months ago
Knowledge discovery through directed probabilistic topic models: a survey
Graphical models have become the basic framework for topic based probabilistic modeling. Especially models with latent variables have proved to be effective in capturing hidden str...
Ali Daud, Juanzi Li, Lizhu Zhou, Faqir Muhammad