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BMCBI
2005
97views more  BMCBI 2005»
15 years 3 months ago
The yeast kinome displays scale free topology with functional hub clusters
Background: The availability of interaction databases provides an opportunity for researchers to utilize immense amounts of data exclusively in silico. Recently there has been an ...
Robin E. C. Lee, Lynn A. Megeney
BMCBI
2005
127views more  BMCBI 2005»
15 years 3 months ago
Are scale-free networks robust to measurement errors?
Background: Many complex random networks have been found to be scale-free. Existing literature on scale-free networks has rarely considered potential false positive and false nega...
Nan Lin, Hongyu Zhao
BMCBI
2005
122views more  BMCBI 2005»
15 years 3 months ago
Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein
Background: Recognition codes for protein-DNA interactions typically assume that the interacting positions contribute additively to the binding energy. While this is known to not ...
Jiajian Liu, Gary D. Stormo
BMCBI
2005
201views more  BMCBI 2005»
15 years 3 months ago
Principal component analysis for predicting transcription-factor binding motifs from array-derived data
Background: The responses to interleukin 1 (IL-1) in human chondrocytes constitute a complex regulatory mechanism, where multiple transcription factors interact combinatorially to...
Yunlong Liu, Matthew P. Vincenti, Hiroki Yokota
BMCBI
2005
163views more  BMCBI 2005»
15 years 3 months ago
CoaSim: A flexible environment for simulating genetic data under coalescent models
Background: Coalescent simulations are playing a large role in interpreting large scale intraspecific sequence or polymorphism surveys and for planning and evaluating association ...
Thomas Mailund, Mikkel H. Schierup, Christian N. S...