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CSB
2005
IEEE
130views Bioinformatics» more  CSB 2005»
15 years 3 months ago
Integration of RNA Search methods for Identifying Novel Riboswitch Patterns in Eukaryotes
Riboswitches are RNA genetic control elements that were recently discovered in living cells. To regulate gene expression, they utilize a unique mechanism whereby small molecules b...
Adaya N. Cohen, Klara Kedem, Michal Shapira, Danny...
CSB
2005
IEEE
117views Bioinformatics» more  CSB 2005»
15 years 3 months ago
Protein Structure Prediction Using Physical-Based Global Optimization and Knowledge-Guided Fragment Packing
We describe a new method to predict the tertiary structure of new-fold proteins. Our two-phase approach combines the knowledge-based fragmentpacking with the minimization of a phy...
Jinhui Ding, Elizabeth Eskow, Nelson L. Max, Silvi...
CSB
2005
IEEE
140views Bioinformatics» more  CSB 2005»
15 years 3 months ago
HIV Structural and Biothermodynamics Databases: a Resource for the Pharmaceutical and Biotechnology Industry
Federal agencies, academia and industries have invested heavily in the development of structural and biothermodynamic data. However, the data are still largely distributed over se...
Talapady N. Bhat, Yadu B. Tewari, Henry Rodriguez,...
CSB
2005
IEEE
110views Bioinformatics» more  CSB 2005»
15 years 3 months ago
Maximum Sequence Alignment Fails to Predict Off-targeted Gene Regulation by RNAi
We have employed various sequence alignment algorithms and scoring techniques to determine whether current computational tools accurately predict genes that will be off-targeted b...
Amanda Birmingham, Emily M. Anderson, William S. M...
CSB
2005
IEEE
163views Bioinformatics» more  CSB 2005»
15 years 3 months ago
A symbolic approach to the simulation of biochemical models: application to circadian rhythms
Symbolic rewriting systems are gaining interest as tools for simulating biochemical dynamics. Compared to traditional methods based on differential equations, the symbolic approac...
Federico Fontana, Luca Bianco, Vincenzo Manca