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JCB
2006
138views more  JCB 2006»
14 years 10 months ago
Recognition and Classification of Histones Using Support Vector Machine
Histones are DNA-binding proteins found in the chromatin of all eukaryotic cells. They are highly conserved and can be grouped into five major classes: H1/H5, H2A, H2B, H3, and H4...
Manoj Bhasin, Ellis L. Reinherz, Pedro A. Reche
NAR
1998
73views more  NAR 1998»
14 years 10 months ago
Identification and characterization of the RAD51 gene from the ciliate Tetrahymena thermophila
The RAD51 gene is a eukaryotic homolog of recA, a critical component in homologous recombination and DNA repair pathways in Escherichia coli. We have cloned the RAD51 homolog from...
Colin Campbell, Daniel P. Romero
72
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IJBRA
2006
107views more  IJBRA 2006»
14 years 10 months ago
Probabilistic models for biological sequences: selection and Maximum Likelihood estimation
: Probabilistic models for biological sequences (DNA and proteins) are frequently used in bioinformatics. We describe statistical tests designed to detect the order of dependency a...
Svetlana Ekisheva, Mark Borodovsky
81
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BMCBI
2006
87views more  BMCBI 2006»
14 years 10 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
BMCBI
2006
98views more  BMCBI 2006»
14 years 10 months ago
Scanning sequences after Gibbs sampling to find multiple occurrences of functional elements
Background: Many DNA regulatory elements occur as multiple instances within a target promoter. Gibbs sampling programs for finding DNA regulatory elements de novo can be prohibiti...
Kannan Tharakaraman, Leonardo Mariño-Ram&ia...