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BMCBI
2007
122views more  BMCBI 2007»
14 years 9 months ago
Dissecting complex transcriptional responses using pathway-level scores based on prior information
Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Harmen J. Bussemaker, Lucas D. Ward, André ...
BMCBI
2007
153views more  BMCBI 2007»
14 years 9 months ago
Analysis of nanopore detector measurements using Machine-Learning methods, with application to single-molecule kinetic analysis
Background: A nanopore detector has a nanometer-scale trans-membrane channel across which a potential difference is established, resulting in an ionic current through the channel ...
Matthew Landry, Stephen Winters-Hilt
BMCBI
2005
180views more  BMCBI 2005»
14 years 9 months ago
arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays
Background: The availability of the human genome sequence as well as the large number of physically accessible oligonucleotides, cDNA, and BAC clones across the entire genome has ...
Björn Menten, Filip Pattyn, Katleen De Preter...
BMCBI
2005
79views more  BMCBI 2005»
14 years 9 months ago
Mathematical design of prokaryotic clone-based microarrays
Background: Clone-based microarrays, on which each spot represents a random genomic fragment, are a good alternative to open reading frame-based microarrays, especially for microo...
Bart Pieterse, Elisabeth J. Quirijns, Frank H. J. ...
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BMCBI
2005
115views more  BMCBI 2005»
14 years 9 months ago
MPrime: efficient large scale multiple primer and oligonucleotide design for customized gene microarrays
Background: Enhancements in sequencing technology have recently yielded assemblies of large genomes including rat, mouse, human, fruit fly, and zebrafish. The availability of larg...
Eric C. Rouchka, Abdelnaby Khalyfa, Nigel G. F. Co...