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BMCBI
2004
124views more  BMCBI 2004»
14 years 9 months ago
Tests for finding complex patterns of differential expression in cancers: towards individualized medicine
Background: Microarray studies in cancer compare expression levels between two or more sample groups on thousands of genes. Data analysis follows a population-level approach (e.g....
James Lyons-Weiler, Satish Patel, Michael J. Becic...
BMCBI
2004
150views more  BMCBI 2004»
14 years 9 months ago
Rank Difference Analysis of Microarrays (RDAM), a novel approach to statistical analysis of microarray expression profiling data
Background: A key step in the analysis of microarray expression profiling data is the identification of genes that display statistically significant changes in expression signals ...
Dietmar E. Martin, Philippe Demougin, Michael N. H...
BMCBI
2004
123views more  BMCBI 2004»
14 years 9 months ago
galaxieEST: addressing EST identity through automated phylogenetic analysis
Background: Research involving expressed sequence tags (ESTs) is intricately coupled to the existence of large, well-annotated sequence repositories. Comparatively complete and sa...
R. Henrik Nilsson, Balaji Rajashekar, Karl-Henrik ...
BMCBI
2004
208views more  BMCBI 2004»
14 years 9 months ago
Hybrid clustering for microarray image analysis combining intensity and shape features
Background: Image analysis is the first crucial step to obtain reliable results from microarray experiments. First, areas in the image belonging to single spots have to be identif...
Jörg Rahnenführer, Daniel Bozinov
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BMCBI
2004
151views more  BMCBI 2004»
14 years 9 months ago
Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics
Background: The general problem of RNA secondary structure prediction under the widely used thermodynamic model is known to be NP-complete when the structures considered include a...
Jens Reeder, Robert Giegerich