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BMCBI
2005
116views more  BMCBI 2005»
14 years 9 months ago
Can Zipf's law be adapted to normalize microarrays?
Background: Normalization is the process of removing non-biological sources of variation between array experiments. Recent investigations of data in gene expression databases for ...
Timothy Lu, Christine M. Costello, Peter J. P. Cro...
BMCBI
2005
118views more  BMCBI 2005»
14 years 9 months ago
Variation in structural location and amino acid conservation of functional sites in protein domain families
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
Birgit Pils, Richard R. Copley, Jörg Schultz
BMCBI
2005
101views more  BMCBI 2005»
14 years 9 months ago
TmaDB: a repository for tissue microarray data
Background: Tissue microarray (TMA) technology has been developed to facilitate large, genome-scale molecular pathology studies. This technique provides a high-throughput method f...
Archana Sharma-Oates, Philip Quirke, David R. West...
BMCBI
2005
167views more  BMCBI 2005»
14 years 9 months ago
Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes
Background: The extensive use of DNA microarray technology in the characterization of the cell transcriptome is leading to an ever increasing amount of microarray data from cancer...
Patrick Warnat, Roland Eils, Benedikt Brors
BMCBI
2005
189views more  BMCBI 2005»
14 years 9 months ago
A sentence sliding window approach to extract protein annotations from biomedical articles
Background: Within the emerging field of text mining and statistical natural language processing (NLP) applied to biomedical articles, a broad variety of techniques have been deve...
Martin Krallinger, Maria Padron, Alfonso Valencia