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BMCBI
2004
150views more  BMCBI 2004»
15 years 5 months ago
Inter-residue distances derived from fold contact propensities correlate with evolutionary substitution costs
Background: The wealth of information on protein structure has led to a variety of statistical analyses of the role played by individual amino acid types in the protein fold. In p...
Gareth Williams, Patrick Doherty
BIOINFORMATICS
1999
65views more  BIOINFORMATICS 1999»
15 years 5 months ago
Genetic Simulation Library
Summary: The Genetic Simulation Library (GSL) is a set of C++ programs and classes that can be used in individualbased simulation models of plant and animal populations. The class...
John S. Conery, Michael Lynch
BMCBI
2007
115views more  BMCBI 2007»
15 years 5 months ago
SpliceMiner: a high-throughput database implementation of the NCBI Evidence Viewer for microarray splice variant analysis
Background: There are many fewer genes in the human genome than there are expressed transcripts. Alternative splicing is the reason. Alternatively spliced transcripts are often sp...
Ari B. Kahn, Michael C. Ryan, Hongfang Liu, Barry ...
158
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BMCBI
2007
126views more  BMCBI 2007»
15 years 5 months ago
Using gene expression data and network topology to detect substantial pathways, clusters and switches during oxygen deprivation
Background: Biochemical investigations over the last decades have elucidated an increasingly complete image of the cellular metabolism. To derive a systems view for the regulation...
Gunnar Schramm, Marc Zapatka, Roland Eils, Rainer ...
189
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BMCBI
2007
153views more  BMCBI 2007»
15 years 5 months ago
A new pairwise kernel for biological network inference with support vector machines
Background: Much recent work in bioinformatics has focused on the inference of various types of biological networks, representing gene regulation, metabolic processes, protein-pro...
Jean-Philippe Vert, Jian Qiu, William Stafford Nob...