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ISMB
1996
13 years 7 months ago
Discovering Patterns and Subfamilies in Biosequences
Weconsider the problemof automaticdiscoveryof patterns and the corresponding subfamilies in a set of biosequences. Thesequences are unaligned and may contain noise of unknownlevel...
Alvis Brazma, Inge Jonassen, Esko Ukkonen, Jaak Vi...
ISMB
1996
13 years 7 months ago
Parameterization Studies for the SAM and HMMER Methods of Hidden Markov Model Generation
Multiple sequence alignment of distantly related viral proteins remains a challenge to all currently available alignment methods. The hidden Markovmodel approach offers a new,flex...
Marcella A. McClure, Chris Smith, Pete Elton
ISMB
1996
13 years 7 months ago
Finding Genes in DNA Using Decision Trees and Dynamic Programming
This study demonstratesthe use of decision tree classifiers as the basis for a general gene-finding system. The system uses a dynamic programmingalgorithm that. finds the optimal ...
Steven Salzberg, Xin Chen, John Henderson, Kenneth...
ISMB
1996
13 years 7 months ago
Discovering Empirically Conserved Amino Acid Substitution Groups in Databases of Protein Families
Thispaperintroducesa methodfor identifyingempirically conservedaminoacid substitution groups.In contrast with existing approachesthat viewaminoacid substitution as a pairwisepheno...
Thomas D. Wu, Douglas L. Brutlag
ISMB
1996
13 years 7 months ago
GeneFisher-Software Support for the Detection of Postulated Genes
Whena family of genes from closely related organisms is known,there is a certain chance to extract the corresponding gene from the genomeof another related organism. This can be d...
Robert Giegerich, Folker Meyer, Chris Schleiermach...