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ISMB
1996
14 years 11 months ago
Discovering Patterns and Subfamilies in Biosequences
Weconsider the problemof automaticdiscoveryof patterns and the corresponding subfamilies in a set of biosequences. Thesequences are unaligned and may contain noise of unknownlevel...
Alvis Brazma, Inge Jonassen, Esko Ukkonen, Jaak Vi...
ISMB
1996
14 years 11 months ago
Parameterization Studies for the SAM and HMMER Methods of Hidden Markov Model Generation
Multiple sequence alignment of distantly related viral proteins remains a challenge to all currently available alignment methods. The hidden Markovmodel approach offers a new,flex...
Marcella A. McClure, Chris Smith, Pete Elton
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ISMB
1996
14 years 11 months ago
Finding Genes in DNA Using Decision Trees and Dynamic Programming
This study demonstratesthe use of decision tree classifiers as the basis for a general gene-finding system. The system uses a dynamic programmingalgorithm that. finds the optimal ...
Steven Salzberg, Xin Chen, John Henderson, Kenneth...
ISMB
1996
14 years 11 months ago
Discovering Empirically Conserved Amino Acid Substitution Groups in Databases of Protein Families
Thispaperintroducesa methodfor identifyingempirically conservedaminoacid substitution groups.In contrast with existing approachesthat viewaminoacid substitution as a pairwisepheno...
Thomas D. Wu, Douglas L. Brutlag
ISMB
1996
14 years 11 months ago
GeneFisher-Software Support for the Detection of Postulated Genes
Whena family of genes from closely related organisms is known,there is a certain chance to extract the corresponding gene from the genomeof another related organism. This can be d...
Robert Giegerich, Folker Meyer, Chris Schleiermach...