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BIOINFORMATICS
2005
93views more  BIOINFORMATICS 2005»
14 years 11 months ago
Donuts, scratches and blanks: robust model-based segmentation of microarray images
Inner holes, artifacts and blank spots are common in microarray images, but current image analysis methods do not pay them enough attention. We propose a new robust model-based me...
Qunhua Li, Chris Fraley, Roger Eugene Bumgarner, K...
BIOINFORMATICS
2005
96views more  BIOINFORMATICS 2005»
14 years 11 months ago
BioLingua: a programmable knowledge environment for biologists
BioLingua is an interactive, web-based programming environment that enables biologists to analyze biological systems by combining knowledge and data through direct end-user progra...
J. P. Massar, Michael Travers, Jeff Elhai, Jeff Sh...
BIOINFORMATICS
2005
152views more  BIOINFORMATICS 2005»
14 years 11 months ago
Intervention in context-sensitive probabilistic Boolean networks
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been...
Ranadip Pal, Aniruddha Datta, Michael L. Bittner, ...
BIOINFORMATICS
2005
72views more  BIOINFORMATICS 2005»
14 years 11 months ago
Use of within-array replicate spots for assessing differential expression in microarray experiments
Motivation. Spotted arrays are often printed with probes in duplicate or triplicate, but current methods for assessing differential expression are not able to make full use of the...
Gordon K. Smyth, Joëlle Michaud, Hamish S. Sc...
BMCBI
2005
81views more  BMCBI 2005»
14 years 11 months ago
Evolutionary sequence analysis of complete eukaryote genomes
Background: Gene duplication and gene loss during the evolution of eukaryotes have hindered attempts to estimate phylogenies and divergence times of species. Although current meth...
Jaime E. Blair, Prachi Shah, S. Blair Hedges
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