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BMCBI
2011
14 years 3 months ago
Efficient alignment of pyrosequencing reads for re-sequencing applications
Background: Over the past few years, new massively parallel DNA sequencing technologies have emerged. These platforms generate massive amounts of data per run, greatly reducing th...
Francisco Fernandes, Paulo G. S. da Fonseca, Lu&ia...
BMCBI
2011
14 years 3 months ago
To aggregate or not to aggregate high-dimensional classifiers
Background: High-throughput functional genomics technologies generate large amount of data with hundreds or thousands of measurements per sample. The number of sample is usually m...
Cheng-Jian Xu, Huub C. J. Hoefsloot, Age K. Smilde
BMCBI
2011
14 years 3 months ago
Fusion of metabolomics and proteomics data for biomarkers discovery: case study on the experimental autoimmune encephalomyelitis
Background: Analysis of Cerebrospinal Fluid (CSF) samples holds great promise to diagnose neurological pathologies and gain insight into the molecular background of these patholog...
Lionel Blanchet, Agnieszka Smolinska, Amos Attali,...
BMCBI
2011
14 years 3 months ago
Smith-Waterman Peak Alignment for Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry
Background: Comprehensive two-dimensional gas chromatography coupled with mass spectrometry (GC × GCMS) is a powerful technique which has gained increasing attention over the las...
Seongho Kim, Imhoi Koo, Aiqin Fang, Xiang Zhang
BMCBI
2011
14 years 3 months ago
Detection of Lineage-Specific Evolutionary Changes among Primate Species
Background: Comparison of the human genome with other primates offers the opportunity to detect evolutionary events that created the diverse phenotypes among the primate species. ...
Mihaela Pertea, Geo Pertea, Steven L. Salzberg