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TCBB
2008
108views more  TCBB 2008»
13 years 5 months ago
Statistical Characterization of Protein Ensembles
When accounting for structural fluctuations or measurement errors, a single rigid structure may not be sufficient to represent a protein. One approach to solve this problem is to r...
Diego Rother, Guillermo Sapiro, Vijay Pande
TCBB
2008
138views more  TCBB 2008»
13 years 6 months ago
PairProSVM: Protein Subcellular Localization Based on Local Pairwise Profile Alignment and SVM
The subcellular locations of proteins are important functional annotations. An effective and reliable subcellular localization method is necessary for proteomics research. This pap...
Man-Wai Mak, Jian Guo, Sun-Yuan Kung
TCBB
2008
82views more  TCBB 2008»
13 years 6 months ago
Efficient Algorithms to Explore Conformation Spaces of Flexible Protein Loops
Two efficient and complementary sampling algorithms are presented to explore the space of closed clash-free conformations of a flexible protein loop. The "seed sampling" ...
Peggy Yao, Ankur Dhanik, Nathan Marz, Ryan Propper...
TCBB
2010
80views more  TCBB 2010»
13 years 4 months ago
On the Importance of Comprehensible Classification Models for Protein Function Prediction
—The literature on protein function prediction is currently dominated by works aimed at maximizing predictive accuracy, ignoring the important issues of validation and interpreta...
Alex Alves Freitas, Daniela Wieser, Rolf Apweiler
TCBB
2008
126views more  TCBB 2008»
13 years 6 months ago
Combinatorial Approaches for Mass Spectra Recalibration
Mass spectrometry has become one of the most popular analysis techniques in Proteomics and Systems Biology. With the creation of larger data sets, the automated recalibration of ma...
Sebastian Böcker, Veli Mäkinen