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114
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BMCBI
2010
177views more  BMCBI 2010»
15 years 25 days ago
Modular composition predicts kinase/substrate interactions
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...
Yichuan Liu, Aydin Tozeren
107
Voted
BMCBI
2010
132views more  BMCBI 2010»
15 years 25 days ago
New statistical potential for quality assessment of protein models and a survey of energy functions
Background: Scoring functions, such as molecular mechanic forcefields and statistical potentials are fundamentally important tools in protein structure modeling and quality assess...
Dmitry Rykunov, András Fiser
132
Voted
BMCBI
2010
202views more  BMCBI 2010»
15 years 25 days ago
NeMo: Network Module identification in Cytoscape
Background: As the size of the known human interactome grows, biologists increasingly rely on computational tools to identify patterns that represent protein complexes and pathway...
Corban G. Rivera, Rachit Vakil, Joel S. Bader
112
Voted
BMCBI
2010
147views more  BMCBI 2010»
15 years 25 days ago
Automatic detection of anchor points for multiple sequence alignment
Background: Determining beforehand specific positions to align (anchor points) has proved valuable for the accuracy of automated multiple sequence alignment (MSA) software. This f...
Florian Pitschi, Claudine Devauchelle, Eduardo Cor...
109
Voted
BMCBI
2010
131views more  BMCBI 2010»
15 years 25 days ago
FACT: Functional annotation transfer between proteins with similar feature architectures
Background: The increasing number of sequenced genomes provides the basis for exploring the genetic and functional diversity within the tree of life. Only a tiny fraction of the e...
Tina Koestler, Arndt von Haeseler, Ingo Ebersberge...