BMCBI
2010
14 years 9 months ago
2010
Background: Accurately covering the conformational space of amino acid side chains is essential for important applications such as protein design, docking and high resolution stru...
BMCBI
2010
14 years 9 months ago
2010
BMCBI
2010
14 years 9 months ago
2010
Background: Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation proces...
BMCBI
2010
14 years 9 months ago
2010
Background: The budding yeast Saccharomyces cerevisiae is one of the most widely studied model organisms in aging-related science. Although several genetic modifiers of yeast long...
BMCBI
2010
14 years 9 months ago
2010
Background: The accumulation of high-throughput data greatly promotes computational investigation of gene function in the context of complex biological systems. However, a biologi...
BMCBI
2010
14 years 9 months ago
2010
Background: The clustered heat map is the most popular means of visualizing genomic data. It compactly displays a large amount of data in an intuitive format that facilitates the ...
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BMCBI
2010
14 years 9 months ago
2010
Background: Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA ...
BMCBI
2010
14 years 9 months ago
2010
Background: This paper deals with the preprocessing of protein sequences for supervised classification. Motif extraction is one way to address that task. It has been largely used ...
BMCBI
2010
14 years 9 months ago
2010
Background: Protein-coding gene detection in prokaryotic genomes is considered a much simpler problem than in intron-containing eukaryotic genomes. However there have been reports...
BMCBI
2010
14 years 9 months ago
2010
Background: Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation o...