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COMPLIFE
2006
Springer
14 years 1 months ago
A New Approach to Flux Coupling Analysis of Metabolic Networks
Flux coupling analysis is a method to identify blocked and coupled reactions in a metabolic network at steady state. We present a new approach to flux coupling analysis, which uses...
Abdelhalim Larhlimi, Alexander Bockmayr
COMPLIFE
2006
Springer
14 years 1 months ago
Set-Oriented Dimension Reduction: Localizing Principal Component Analysis Via Hidden Markov Models
We present a method for simultaneous dimension reduction and metastability analysis of high dimensional time series. The approach is based on the combination of hidden Markov model...
Illia Horenko, Johannes Schmidt-Ehrenberg, Christo...
COMPLIFE
2006
Springer
14 years 1 months ago
High-Throughput Identification of Chemistry in Life Science Texts
. OSCAR3 is an open extensible system for the automated annotation of chemistry in scientific articles, which can process thousands of articles per hour. This XML annotation suppor...
Peter Corbett, Peter Murray-Rust
COMPLIFE
2006
Springer
14 years 1 months ago
Beating the Noise: New Statistical Methods for Detecting Signals in MALDI-TOF Spectra Below Noise Level
Background: The computer-assisted detection of small molecules by mass spectrometry in biological samples provides a snapshot of thousands of peptides, protein fragments and prote...
Tim O. F. Conrad, Alexander Leichtle, Andre Hageh&...
COMPLIFE
2006
Springer
14 years 1 months ago
A Point-Matching Based Algorithm for 3D Surface Alignment of Drug-Sized Molecules
Abstract. Molecular shapes play an important role in molecular interactions, e.g., between a protein and a ligand. The `outer' shape of a molecule can be approximated by its s...
Daniel Baum, Hans-Christian Hege
COMPLIFE
2006
Springer
14 years 1 months ago
The Language of Cortical Dynamics
Péter András
COMPLIFE
2006
Springer
14 years 1 months ago
Promoter Prediction Using Physico-Chemical Properties of DNA
The ability to locate promoters within a section of DNA is known to be a very difficult and very important task in DNA analysis. We document an approach that incorporates the conce...
Philip Uren, R. Mike Cameron-Jones, Arthur H. J. S...
COMPLIFE
2006
Springer
14 years 1 months ago
Adaptive Approach for Modelling Variability in Pharmacokinetics
Abstract. We present an improved adaptive approach for studying systems of ODEs affected by parameter variability and state space uncertainty. Our approach is based on a reformulat...
Andrea Y. Weiße, Illia Horenko, Wilhelm Huis...
COMPLIFE
2006
Springer
14 years 1 months ago
Relational Subgroup Discovery for Descriptive Analysis of Microarray Data
Abstract. This paper presents a method that uses gene ontologies, together with the paradigm of relational subgroup discovery, to help find description of groups of genes different...
Igor Trajkovski, Filip Zelezný, Jakub Tolar...
COMPLIFE
2006
Springer
14 years 1 months ago
Software Supported Modelling in Pharmacokinetics
A powerful new software concept to physiologically based pharmacokinetic (PBPK) modelling of drug disposition is presented. It links the inherent modular understanding in pharmacol...
Regina Telgmann, Max von Kleist, Wilhelm Huisinga