217views Hardware» more  CAV 2011»
12 years 9 months ago
From Cardiac Cells to Genetic Regulatory Networks
Abstract. A fundamental question in the treatment of cardiac disorders, such as tachycardia and fibrillation, is under what circumstances does such a disorder arise? To answer to ...
Radu Grosu, Grégory Batt, Flavio H. Fenton,...
127views more  AUTOMATICA 2010»
13 years 3 months ago
Partitioning datasets based on equalities among parameters
When a phenomenon is described by a parametric model and multiple datasets are available, a key problem in statistics is to discover which datasets are characterized by the same p...
Riccardo Porreca, Giancarlo Ferrari-Trecate
267views Neural Networks» more  NN 2007»
13 years 5 months ago
Modeling of gene regulatory networks with hybrid differential evolution and particle swarm optimization
In the last decade, recurrent neural networks (RNNs) have attracted more efforts in inferring genetic regulatory networks (GRNs), using time series gene expression data from micro...
Rui Xu, Ganesh K. Venayagamoorthy, Donald C. Wunsc...
131views more  JCB 2002»
13 years 5 months ago
Modeling and Simulation of Genetic Regulatory Systems: A Literature Review
In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The reg...
Hidde de Jong
122views more  BMCBI 2005»
13 years 5 months ago
A microarray data-based semi-kinetic method for predicting quantitative dynamics of genetic networks
Background: Elucidating the dynamic behaviour of genetic regulatory networks is one of the most significant challenges in systems biology. However, conventional quantitative predi...
Katsuyuki Yugi, Yoichi Nakayama, Shigen Kojima, To...
116views more  TCBB 2008»
13 years 5 months ago
Inferring Connectivity of Genetic Regulatory Networks Using Information-Theoretic Criteria
Recently, the concept of mutual information has been proposed for inferring the structure of genetic regulatory networks from gene expression profiling. After analyzing the limitat...
Wentao Zhao, Erchin Serpedin, Edward R. Dougherty
119views more  IJDMB 2007»
13 years 5 months ago
Simulation study in Probabilistic Boolean Network models for genetic regulatory networks
: Probabilistic Boolean Network (PBN) is widely used to model genetic regulatory networks. Evolution of the PBN is according to the transition probability matrix. Steady-state (lon...
Shuqin Zhang, Wai-Ki Ching, Michael K. Ng, Tatsuya...
127views more  BMCBI 2006»
13 years 5 months ago
On the attenuation and amplification of molecular noise in genetic regulatory networks
Background: Noise has many important roles in cellular genetic regulatory functions at the nanomolar scale. At present, no good theory exists for identifying all possible mechanis...
Bor-Sen Chen, Yu-Chao Wang
13 years 7 months ago
Qualitative Simulation of Genetic Regulatory Networks: Method and Application
Computer modeling and simulation are indispensable for understanding the functioning of an organism on a molecular level. We present an implemented method for the qualitative simu...
Hidde de Jong, Michel Page, Céline Hernande...
13 years 7 months ago
Temporal Logic Patterns for Querying Qualitative Models of Genetic Regulatory Networks
Formal verification based on model checking provides a powerful technology to query qualitative models of dynamical systems. The application of model-checking approaches is hamper...
Pedro T. Monteiro, Delphine Ropers, Radu Mateescu,...