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BMCBI
2011
13 years 2 months ago
Detection of Lineage-Specific Evolutionary Changes among Primate Species
Background: Comparison of the human genome with other primates offers the opportunity to detect evolutionary events that created the diverse phenotypes among the primate species. ...
Mihaela Pertea, Geo Pertea, Steven L. Salzberg
ISBRA
2010
Springer
13 years 9 months ago
A Consensus Tree Approach for Reconstructing Human Evolutionary History and Detecting Population Substructure
The random accumulation of variations in the human genome over time implicitly encodes a history of how human populations have arisen, dispersed, and intermixed since we emerged as...
Ming-Chi Tsai, Guy E. Blelloch, R. Ravi, Russell S...
NAR
2002
111views more  NAR 2002»
13 years 10 months ago
DNA Data Bank of Japan (DDBJ) for genome scale research in life science
The DNA Data Bank of Japan (DDBJ, http:// www.ddbj.nig.ac.jp) has made an effort to collect as much data as possible mainly from Japanese researchers. The increase rates of the da...
Yoshio Tateno, Tadashi Imanishi, Satoru Miyazaki, ...
NAR
2002
109views more  NAR 2002»
13 years 10 months ago
The Molecular Biology Database Collection: 2002 update
The Molecular Biology Database Collection is an online resource listing key databases of value to the biological community. This Collection is intended to bring fellow scientists&...
Andreas D. Baxevanis
JACM
2002
94views more  JACM 2002»
13 years 10 months ago
The greedy path-merging algorithm for contig scaffolding
Given a collection of contigs and mate-pairs. The Contig Scaffolding Problem is to order and orientate the given contigs in a manner that is consistent with as many mate-pairs as p...
Daniel H. Huson, Knut Reinert, Eugene W. Myers
BMCBI
2005
114views more  BMCBI 2005»
13 years 11 months ago
Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and stru
Background: Protein kinases are a well defined family of proteins, characterized by the presence of a common kinase catalytic domain and playing a significant role in many importa...
Luciano Milanesi, Mauro Petrillo, Leandra Sepe, An...
BMCBI
2005
133views more  BMCBI 2005»
13 years 11 months ago
Ab initio identification of putative human transcription factor binding sites by comparative genomics
Background: Understanding transcriptional regulation of gene expression is one of the greatest challenges of modern molecular biology. A central role in this mechanism is played b...
Davide Corà, Carl Herrmann, Christoph Diete...
BMCBI
2008
107views more  BMCBI 2008»
13 years 11 months ago
Probe-specific mixed-model approach to detect copy number differences using multiplex ligation-dependent probe amplification (ML
Background: MLPA method is a potentially useful semi-quantitative method to detect copy number alterations in targeted regions. In this paper, we propose a method for the normaliz...
Juan R. González, Josep L. Carrasco, Llu&ia...
BMCBI
2008
118views more  BMCBI 2008»
13 years 11 months ago
PseudoGeneQuest - Service for identification of different pseudogene types in the human genome
Background: Pseudogenes, nonfunctional copies of genes, evolve fast due the lack of evolutionary pressures and thus appear in several different forms. PseudoGeneQuest is an online...
Csaba P. Ortutay, Mauno Vihinen
BMCBI
2010
122views more  BMCBI 2010»
13 years 11 months ago
Genome3D: A viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional
Background: New technologies are enabling the measurement of many types of genomic and epigenomic information at scales ranging from the atomic to nuclear. Much of this new data i...
Thomas M. Asbury, Matt Mitman, Jijun Tang, W. Jim ...