112views more  SCFBM 2008»
13 years 5 months ago
The Multiscale Systems Immunology project: software for cell-based immunological simulation
Background: Computer simulations are of increasing importance in modeling biological phenomena. Their purpose is to predict behavior and guide future experiments. The aim of this ...
Faheem Mitha, Timothy A. Lucas, Feng Feng, Thomas ...
133views more  TEC 2002»
13 years 5 months ago
Learning and optimization using the clonal selection principle
The clonal selection principle is used to explain the basic features of an adaptive immune response to an antigenic stimulus. It establishes the idea that only those cells that rec...
Leandro Nunes de Castro, Fernando J. Von Zuben
104views more  BMCBI 2010»
13 years 6 months ago
Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy
Background: Several diseases, many of which nowadays pandemic, consist of multifactorial pathologies. Paradigmatic examples come from the immune response to pathogens, in which ca...
Anil Sorathiya, Andrea Bracciali, Pietro Liò...
101views Bioinformatics» more  CSB 2003»
13 years 11 months ago
Stochastic Stage-structured Modeling of the Adaptive Immune System
We have constructed a computer model of the cytotoxic T lymphocyte (CTL) response to antigen and the maintenance of immunological memory. Because immune responses often begin with...
Dennis L. Chao, Miles P. Davenport, Stephanie Forr...
14 years 18 days ago
Evolution Induced Secondary Immunity: An Artificial Immune System Based Intrusion Detection System
The analogy between Immune Systems and Intrusion Detection Systems encourage the use of Artificial Immune Systems for anomaly detection in computer networks. This paper describes ...
Divyata Dal, Siby Abraham, Ajith Abraham, Sugata S...