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BMCBI
2004
96views more  BMCBI 2004»
15 years 2 days ago
Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides
Background: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequen...
Olga V. Matveeva, Brian T. Foley, Vladimir A. Nemt...
94
Voted
TCBB
2008
113views more  TCBB 2008»
15 years 4 days ago
Efficient Algorithms for the Computational Design of Optimal Tiling Arrays
The representation of a genome by oligonucleotide probes is a prerequisite for the analysis of many of its basic properties, such as transcription factor binding sites, chromosomal...
Alexander Schliep, Roland Krause
90
Voted
IJBRA
2008
98views more  IJBRA 2008»
15 years 7 days ago
Computationally Optimised DNA Assembly of synthetic genes
: Gene synthesis is hampered by two obstacles:
Liza S. Z. Larsen, Christopher D. Wassman, G. Wesl...