120views more  BMCBI 2002»
13 years 7 months ago
tacg - a grep for DNA
Background: Pattern matching is the core of bioinformatics; it is used in database searching, restriction enzyme mapping, and finding open reading frames. It is done repeatedly ov...
Harry Mangalam
137views more  BMCBI 2002»
13 years 7 months ago
ORFer - retrieval of protein sequences and open reading frames from GenBank and storage into relational databases or text files
Background: Functional genomics involves the parallel experimentation with large sets of proteins. This requires management of large sets of open reading frames as a prerequisite ...
Konrad Büssow, Steve Hoffmann, Volker Sievert
117views more  BMCBI 2006»
13 years 7 months ago
Gene Designer: a synthetic biology tool for constructing artificial DNA segments
Background: Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi re...
Alan Villalobos, Jon E. Ness, Claes Gustafsson, Je...
13 years 8 months ago
Pattern Recognition of Genomic Features with Microarrays: Site Typing of Mycobacterium Tuberculosis Strains
Mycobacterium tuberculosis (M. tb.) strains differ in the number and locations of a transposon-like insertion sequence known as IS6110. Accurate detection of this sequence can be ...
Soumya Raychaudhuri, Joshua M. Stuart, Xuemin Liu,...
14 years 1 months ago
Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
— The way evolution shapes the arrangement of synonymous codons within open reading frames (ORF) for fine tuning mRNA decoding efficiency is not yet understood. Since the ribosom...
José P. Lousado, Gabriela R. Moura, Manuel ...
14 years 2 months ago
Towards Automatic Detecting of Overlapping Genes - Clustered BLAST Analysis of Viral Genomes
Overlapping genes (encoded on the same DNA strand but in different frames) are thought to be rare and, therefore, were largely neglected in the past. In a test set of 800 viruses ...
Klaus Neuhaus, Daniela Oelke, David Fürst, Si...