11 years 7 months ago
Reconstructing Boolean Models of Signaling
Abstract. Since the first emergence of protein-protein interaction networks, more than a decade ago, they have been viewed as static scaffolds of the signaling-regulatory events ...
Roded Sharan, Richard M. Karp
196views Data Mining» more  KDD 2012»
11 years 8 months ago
Chromatic correlation clustering
We study a novel clustering problem in which the pairwise relations between objects are categorical. This problem can be viewed as clustering the vertices of a graph whose edges a...
Francesco Bonchi, Aristides Gionis, Francesco Gull...
370views Healthcare» more  IHI 2012»
12 years 1 months ago
FUSE: a system for data-driven multi-level functional summarization of protein interaction networks
Despite recent progress in high-throughput experimental studies, systems level visualization and analysis of large protein interaction networks (ppi) remains a challenging task, g...
Boon-Siew Seah, Sourav S. Bhowmick, Charles Forbes...
307views Data Mining» more  SDM 2011»
12 years 8 months ago
Block-LDA: Jointly modeling entity-annotated text and entity-entity links
We present a model that improves entity entity link modeling in a mixed membership stochastic block model, by jointly modeling links with text about the entities that are linked i...
Ramnath Balasubramanyan, William W. Cohen
252views Computer Vision» more  NAR 2011»
12 years 8 months ago
BISC: Binary SubComplexes in proteins database
Binary subcomplexes in proteins database (BISC) is a new protein–protein interaction (PPI) database linking up the two communities most active in their characterization: structu...
Thomas Juettemann, Dietlind L. Gerloff
223views Computer Vision» more  NAR 2011»
12 years 8 months ago
KUPS: constructing datasets of interacting and non-interacting protein pairs with associated attributions
KUPS (The University of Kansas Proteomics Service) provides high-quality protein–protein interaction (PPI) data for researchers developing and evaluating computational models fo...
Xue-wen Chen, Jong Cheol Jeong, Patrick Dermyer
257views Computer Vision» more  NAR 2011»
12 years 8 months ago
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
An essential prerequisite for any systems-level understanding of cellular functions is to correctly uncover and annotate all functional interactions among proteins in the cell. To...
Damian Szklarczyk, Andrea Franceschini, Michael Ku...
214views Computer Vision» more  NAR 2011»
12 years 8 months ago
DAnCER: Disease-Annotated Chromatin Epigenetics Resource
Chromatin modification (CM) is a set of epigenetic processes that govern many aspects of DNA replication, transcription and repair. CM is carried out by groups of physically inter...
Andrei L. Turinsky, Brian Turner, Rosanne C. Borja...
12 years 9 months ago
MINE: Module Identification in NEtworks
Background: Graphical models of network associations are useful for both visualizing and integrating multiple types of association data. Identifying modules, or groups of function...
Kahn Rhrissorrakrai, Kristin C. Gunsalus
12 years 9 months ago
When the Web meets the cell: using personalized PageRank for analyzing protein interaction networks
Motivation: Enormous, and constantly increasing quantity of biological information is represented in protein interaction network databases. Most of these data are freely accessibl...
Gábor Iván, Vince Grolmusz