BMCBI
2008
13 years 6 months ago
2008
Background: Structural similarities among proteins can provide valuable insight into their functional mechanisms and relationships. As the number of available three-dimensional (3...
BMCBI
2010
13 years 6 months ago
2010
Background: Folding of a protein into its three dimensional structure is influenced by both local and global interactions within a protein. Higher order residue interactions, like...
BMCBI
2010
13 years 6 months ago
2010
Background: Protein structure comparison is a fundamental task in structural biology. While the number of known protein structures has grown rapidly over the last decade, searchin...
BMCBI
2010
13 years 6 months ago
2010
Background: The current advances in electron cryo-microscopy technique have made it possible to obtain protein density maps at about 6-10
BMCBI
2010
13 years 6 months ago
2010
Background: Recombinant protein production is a useful biotechnology to produce a large quantity of highly soluble proteins. Currently, the most widely used production system is t...
BMCBI
2010
13 years 6 months ago
2010
Background: Post-translational modifications (PTMs) have a key role in regulating cell functions. Consequently, identification of PTM sites has a significant impact on understandi...
BMCBI
2010
13 years 6 months ago
2010
Background: Prediction of protein localization in subnuclear organelles is more challenging than general protein subcelluar localization. There are only three computational models...
BMCBI
2010
13 years 6 months ago
2010
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...
BMCBI
2010
13 years 6 months ago
2010
Background: Efficient dissection of large proteins into their structural domains is critical for high throughput proteome analysis. So far, no study has focused on mathematically ...
BMCBI
2010
13 years 6 months ago
2010
Background: Guanosine triphosphate (GTP)-binding proteins play an important role in regulation of G-protein. Thus prediction of GTP interacting residues in a protein is one of the...