A High-Throughput Bioinformatics Platform for Mass Spectrometry-Based Proteomics

The success of mass spectrometry-based proteomics in emerging applications such as biomarker discovery and clinical diagnostics, is predicated substantially on its ability to achieve growing demands for throughput. Support for high throughput implies sophisticated tracking of experiments and the experimental steps, larger amounts of data to be organized and summarized, more complex algorithms for inferring and tracking protein expression across multiple experiments, statistical methods to access data quality, and a streamlined proteomics-centric bioinformatics environment to establish the biological context and relevance of the experimental measurements. This paper presents a bioinformatics platform that was built for an industrial mass spectrometry-based proteomics laboratory focusing on biomarker discovery. The basis of the platform is a robust and scalable information management environment supported by database and workflow management technology that is employed for the integration...

• Type: Conference
• Year: 2007
• Where: DILS
• Authors: Thodoros Topaloglou, Moyez Dharsee, Rob M. Ewing, Yury V. Bukhman
• Keywords: Life Sciences, Biomarker Discovery, DILS 2007, Mass Spectrometry-based Proteomics, Protein Expression