A comparative study of conservation and variation scores

Background: Conservation and variation scores are used when evaluating sites in a multiple sequence alignment, in order to identify residues critical for structure or function. A variety of scores are available today but it is not clear how different scores relate to each other. Results: We applied 25 conservation and variation scores to alignments from the Catalytic Site Atlas (CSA). We calculated distances among scores based on correlation coefficients, and constructed a dendrogram of the scores by average linking cluster analysis. The cluster analysis showed that most scores fall into one of two groups

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Fredrik Johansson, Hiroyuki Toh
• Keywords: BMCBI 2010, Catalytic Sites, Cluster Analysis, Variation Scores