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ISBRA
2007
Springer

Reconstruction of 3D Structures from Protein Contact Maps

11 years 7 months ago
Reconstruction of 3D Structures from Protein Contact Maps
Proteins are large organic compounds made of amino acids arranged in a linear chain (primary structure). Most proteins fold into unique threedimensional (3D) structures called interchangeably tertiary, folded, or native structures. Discovering the tertiary structure of a protein (Protein Folding Problem) can provide important clues about how the protein performs its function and it is one of the most important problems in Bioinformatics. A contact map of a given protein P is a binary matrix M such that Mi,j = 1 iff the physical distance between amino acids i and j in the native structure is less than or equal to a pre-assigned threshold t. The contact map of each protein is a distinctive signature of its folded structure. Predicting the tertiary structure of a protein directly from its primary structure is a very complex and still unsolved problem. An alternative and probably more feasible approach is to predict the contact map of a protein from its primary structure and then to comput...
Marco Vassura, Luciano Margara, Filippo Medri, Pie
Added 08 Jun 2010
Updated 08 Jun 2010
Type Conference
Year 2007
Where ISBRA
Authors Marco Vassura, Luciano Margara, Filippo Medri, Pietro di Lena, Piero Fariselli, Rita Casadio
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