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BMCBI
2010
99views more  BMCBI 2010»
13 years 5 months ago
Different effects of the probe summarization algorithms PLIER and RMA on high-level analysis of Affymetrix exon arrays
Background: Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized pla...
Yi Qu, Fei He, Yuchen Chen
NIPS
2004
13 years 6 months ago
Probabilistic Inference of Alternative Splicing Events in Microarray Data
Alternative splicing (AS) is an important and frequent step in mammalian gene expression that allows a single gene to specify multiple products, and is crucial for the regulation ...
Ofer Shai, Brendan J. Frey, Quaid Morris, Qun Pan,...
ACMSE
2007
ACM
13 years 9 months ago
Finding association rules of cis-regulatory elements involved in alternative splicing
Alternative splicing (AS) is a major mechanism to generate protein diversity. A single gene might generate hundreds or even thousands of different proteins. Recently, powerful lar...
Jihye Kim, Sihui Zhao, Steffen Heber
CMSB
2003
Springer
13 years 10 months ago
Multiscale Modeling of Alternative Splicing Regulation
Alternative splicing is a key process in post-transcriptional regulation, by which several kinds of mature RNA can be obtained from the same premessenger RNA. Using a constraint pr...
Damien Eveillard, Delphine Ropers, Hidde de Jong, ...
BIBE
2007
IEEE
125views Bioinformatics» more  BIBE 2007»
13 years 11 months ago
Large-scale Discovery of Regulatory Motifs Involved in Alternative Splicing
Alternative splicing is a highly important process in many eukaryotic organisms, but surprisingly little is known about its regulation. Often, this process involves cis-regulatory ...
Sihui Zhao, Jihye Kim, Steffen Heber
BIBM
2008
IEEE
137views Bioinformatics» more  BIBM 2008»
13 years 11 months ago
Exploring Alternative Splicing Features Using Support Vector Machines
Alternative splicing is a mechanism for generating different gene transcripts (called isoforms) from the same genomic sequence. Finding alternative splicing events experimentally ...
Jing Xia, Doina Caragea, Susan Brown
BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
13 years 11 months ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber