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BIBM
2010
IEEE
161views Bioinformatics» more  BIBM 2010»
8 years 7 months ago
Cis-regulatory module detection using constraint programming
We propose a method for finding CRMs in a set of co-regulated genes. Each CRM consists of a set of binding sites of transcription factors. We wish to find CRMs involving the same t...
Tias Guns, Hong Sun, Kathleen Marchal, Siegfried N...
NAR
2007
115views more  NAR 2007»
8 years 8 months ago
PReMod: a database of genome-wide mammalian cis-regulatory module predictions
We describe PReMod, a new database of genomewide cis-regulatory module (CRM) predictions for both the human and the mouse genomes. The prediction algorithm, described previously i...
Vincent Ferretti, Christian Poitras, Dominique Ber...
BMCBI
2005
94views more  BMCBI 2005»
8 years 9 months ago
Measuring similarities between transcription factor binding sites
Background: Collections of transcription factor binding profiles (Transfac, Jaspar) are essential to identify regulatory elements in DNA sequences. Subsets of highly similar profi...
Szymon M. Kielbasa, Didier Gonze, Hanspeter Herzel
BMCBI
2005
115views more  BMCBI 2005»
8 years 9 months ago
SUPERFICIAL - Surface mapping of proteins via structure-based peptide library design
Background: The determination of protein surfaces and the detection of binding sites are essential to our understanding of protein-protein interactions. Such binding sites can be ...
Andrean Goede, Ines S. Jaeger, Robert Preissner
TCBB
2008
103views more  TCBB 2008»
8 years 9 months ago
DNA Motif Representation with Nucleotide Dependency
The problem of discovering novel motifs of binding sites is important to the understanding of gene regulatory networks. Motifs are generally represented by matrices (PWM or PSSM) o...
Francis Y. L. Chin, Henry C. M. Leung
BMCBI
2007
115views more  BMCBI 2007»
8 years 9 months ago
Local comparison of protein structures highlights cases of convergent evolution in analogous functional sites
Background: We performed an exhaustive search for local structural similarities in an ensemble of non-redundant protein functional sites. With the purpose of finding new examples ...
Gabriele Ausiello, Daniele Peluso, Allegra Via, Ma...
BMCBI
2007
128views more  BMCBI 2007»
8 years 9 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne
BMCBI
2007
148views more  BMCBI 2007»
8 years 9 months ago
fREDUCE: Detection of degenerate regulatory elements using correlation with expression
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
Randy Z. Wu, Christina Chaivorapol, Jiashun Zheng,...
BMCBI
2006
124views more  BMCBI 2006»
8 years 9 months ago
Predicting transcription factor binding sites using local over-representation and comparative genomics
Background: Identifying cis-regulatory elements is crucial to understanding gene expression, which highlights the importance of the computational detection of overrepresented tran...
Matthieu Defrance, Hélène Touzet
BMCBI
2006
137views more  BMCBI 2006»
8 years 9 months ago
Bounded search for de novo identification of degenerate cis-regulatory elements
Background: The identification of statistically overrepresented sequences in the upstream regions of coregulated genes should theoretically permit the identification of potential ...
Jonathan M. Carlson, Arijit Chakravarty, Radhika S...
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