BMCBI
2007
13 years 4 months ago
2007
Background: The need to build a tool to facilitate the quick creation and editing of models encoded in the Systems Biology Markup language (SBML) has been growing with the number ...
BMCBI
2007
13 years 4 months ago
2007
Background: Since real time PCR was first developed, several approaches to estimating the initial quantity of template in an RT-PCR reaction have been tried. While initially only ...
BMCBI
2007
13 years 4 months ago
2007
Background: The rapid burgeoning of available protein data makes the use of clustering within families of proteins increasingly important. The challenge is to identify subfamilies...
BMCBI
2007
13 years 4 months ago
2007
Background: Detection of short, subtle conserved motif regions within a set of related DNA or amino acid sequences can lead to discoveries about important regulatory domains such ...
BMCBI
2007
13 years 4 months ago
2007
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
BMCBI
2007
13 years 4 months ago
2007
Background: The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure ...
BMCBI
2007
13 years 4 months ago
2007
Background: Microarray techniques survey gene expressions on a global scale. Extensive biomedical studies have been designed to discover subsets of genes that are associated with ...
BMCBI
2007
13 years 4 months ago
2007
Background: When conducting multiple hypothesis tests, it is important to control the number of false positives, or the False Discovery Rate (FDR). However, there is a tradeoff be...
BMCBI
2007
13 years 4 months ago
2007
Background: Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has become one of the most used tools in mass spectrometry based proteomics. Various algorithms ...
BMCBI
2007
13 years 4 months ago
2007
Background: Data clustering analysis has been extensively applied to extract information from gene expression profiles obtained with DNA microarrays. To this aim, existing cluster...