BMCBI
2010
13 years 5 months ago
2010
Background: Successful application of crosslinking combined with mass spectrometry for studying proteins and protein complexes requires specifically-designed crosslinking reagents...
BMCBI
2010
13 years 5 months ago
2010
Background: Co-evolution is the process in which two (or more) sets of orthologs exhibit a similar or correlative pattern of evolution. Co-evolution is a powerful way to learn abo...
BMCBI
2010
13 years 5 months ago
2010
Background: A major goal of molecular biology is determining the mechanisms that control the transcription of genes. Motif Enrichment Analysis (MEA) seeks to determine which DNA-b...
BMCBI
2010
13 years 5 months ago
2010
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
BMCBI
2010
13 years 5 months ago
2010
Background: The development of DNA microarrays has facilitated the generation of hundreds of thousands of transcriptomic datasets. The use of a common reference microarray design ...
BMCBI
2010
13 years 5 months ago
2010
Background: Minimotifs are short peptide sequences within one protein, which are recognized by other proteins or molecules. While there are now several minimotif databases, they a...
BMCBI
2010
13 years 5 months ago
2010
Background: Several bioinformatic approaches have previously been used to find novel sites of ADAR mediated A-to-I RNA editing in human. These studies have discovered thousands of...
BMCBI
2010
13 years 5 months ago
2010
Background: Analysis of data from high-throughput experiments depends on the availability of well-structured data that describe the assayed biomolecules. Procedures for obtaining ...
BMCBI
2010
13 years 5 months ago
2010
Background: Ab initio protein structure prediction methods generate numerous structural candidates, which are referred to as decoys. The decoy with the most number of neighbors of...
BMCBI
2010
13 years 5 months ago
2010
Background: Gene/protein recognition and normalization are important preliminary steps for many biological text mining tasks, such as information retrieval, protein-protein intera...