BMCBI
2010
13 years 5 months ago
2010
Background: It has been long well known that genes do not act alone; rather groups of genes act in consort during a biological process. Consequently, the expression levels of gene...
BMCBI
2010
13 years 5 months ago
2010
Background: Genome sequence alignments form the basis of much research. Genome alignment depends on various mundane but critical choices, such as how to mask repeats and which sco...
BMCBI
2010
2010
Orientation-dependent backbone-only residue pair scoring functions for fixed backbone protein design
13 years 5 months ago
Background: Empirical scoring functions have proven useful in protein structure modeling. Most such scoring functions depend on protein side chain conformations. However, backbone...
BMCBI
2010
13 years 5 months ago
2010
Background: Epistatic miniarray profiling (E-MAPs) is a high-throughput approach capable of quantifying aggravating or alleviating genetic interactions between gene pairs. The dat...
BMCBI
2010
13 years 5 months ago
2010
Background: Observed co-expression of a group of genes is frequently attributed to co-regulation by shared transcription factors. This assumption has led to the hypothesis that pr...
BMCBI
2010
13 years 5 months ago
2010
Background: Random forests (RF) have been increasingly used in applications such as genome-wide association and microarray studies where predictor correlation is frequently observ...
BMCBI
2010
13 years 5 months ago
2010
Background: In HIV treatment it is critical to have up-to-date resistance data of applicable drugs since HIV has a very high rate of mutation. These data are made available throug...
BMCBI
2010
13 years 5 months ago
2010
Background: Enzymes belonging to acyl:CoA synthetase (ACS) superfamily activate wide variety of substrates and play major role in increasing the structural and functional diversit...
BMCBI
2010
13 years 5 months ago
2010
Background: Protein loops encompass 50% of protein residues in available three-dimensional structures. These regions are often involved in protein functions, e.g. binding site, ca...
BMCBI
2010
13 years 5 months ago
2010
Background: High-throughput screens comparing growth rates of arrays of distinct micro-organism cultures on solid agar are useful, rapid methods of quantifying genetic interaction...