Name ambiguity problem has raised urgent demands for efficient, high-quality named entity disambiguation methods. In recent years, the increasing availability of large-scale, rich semantic knowledge sources (such as Wikipedia and WordNet) creates new opportunities to enhance the named entity disambiguation by developing algorithms which can exploit these knowledge sources at best. The problem is that these knowledge sources are heterogeneous and most of the semantic knowledge within them is embedded in complex structures, such as graphs and networks. This paper proposes a knowledge-based method, called Structural Semantic Relatedness (SSR), which can enhance the named entity disambiguation by capturing and leveraging the structural semantic knowledge in multiple knowledge sources. Empirical results show that, in comparison with the classical BOW based methods and social network based methods, our method can significantly improve the disambiguation performance by respectively 8.7% and ...