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» A Methodology for Comparative Functional Genomics
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NAR
2000
120views more  NAR 2000»
14 years 9 months ago
WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction
The WIT (What Is There) (http://wit.mcs.anl.gov/WIT2/ ) system has been designed to support comparative analysis of sequenced genomes and to generate metabolic reconstructions bas...
Ross A. Overbeek, Niels Larsen, Gordon D. Pusch, M...
72
Voted
BMCBI
2007
125views more  BMCBI 2007»
14 years 9 months ago
Statistical tests to compare motif count exceptionalities
Background: Finding over- or under-represented motifs in biological sequences is now a common task in genomics. Thanks to p-value calculation for motif counts, exceptional motifs ...
Stéphane Robin, Sophie Schbath, Vincent Van...
RECOMB
2009
Springer
15 years 4 months ago
Reconstructing Histories of Complex Gene Clusters on a Phylogeny
Abstract. Clusters of genes that have evolved by repeated segmental duplication present difficult challenges throughout genomic analysis, from sequence assembly to functional analy...
Tomás Vinar, Brona Brejová, Giltae S...
BMCBI
2010
128views more  BMCBI 2010»
14 years 9 months ago
VIGOR, an annotation program for small viral genomes
Background: The decrease in cost for sequencing and improvement in technologies has made it easier and more common for the re-sequencing of large genomes as well as parallel seque...
Shiliang Wang, Jaideep P. Sundaram, David Spiro
90
Voted
BMCBI
2005
102views more  BMCBI 2005»
14 years 9 months ago
Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computatio
Background: A major challenge in computational genomics is the development of methodologies that allow accurate genome-wide prediction of the regulatory targets of a transcription...
Emmitt R. Jolly, Chen-Shan Chin, Ira Herskowitz, H...