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» A Methodology for Comparative Functional Genomics
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ALMOB
2006
109views more  ALMOB 2006»
14 years 9 months ago
A novel functional module detection algorithm for protein-protein interaction networks
Background: The sparse connectivity of protein-protein interaction data sets makes identification of functional modules challenging. The purpose of this study is to critically eva...
Woochang Hwang, Young-Rae Cho, Aidong Zhang, Mural...
BMCBI
2008
138views more  BMCBI 2008»
14 years 9 months ago
Comparative analyses of bidirectional promoters in vertebrates
Background: Orthologous genes with deep phylogenetic histories are likely to retain similar regulatory features. In this report we utilize orthology assignments for pairs of genes...
Mary Qu Yang, James Taylor, Laura Elnitski
BMCBI
2010
101views more  BMCBI 2010»
14 years 9 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
IQ
2003
14 years 11 months ago
Data Quality in Genome Databases
: Genome databases store data about molecular biological entities such as genes, proteins, diseases, etc. The main purpose of creating and maintaining such databases in commercial ...
Heiko Müller, Felix Naumann
BMCBI
2008
99views more  BMCBI 2008»
14 years 9 months ago
Multiple organism algorithm for finding ultraconserved elements
Background: Ultraconserved elements are nucleotide or protein sequences with 100% identity (no mismatches, insertions, or deletions) in the same organism or between two or more or...
Scott Christley, Neil F. Lobo, Gregory R. Madey